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How to get fromSt. Louis to Knoxvilleby plane, bus (Greyhound), train, bus or car

Find Transport to Knoxville

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There are 8 ways to get from St. Louis to Knoxville by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    5h 12m
    $198–972

  2. Drive 481.5 mi

    cheapest
    1. Drive from St. Louis to Knoxvillecar car 481.5 mi
    7h 57m
    $88–127

  3. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    38h 18m
    $261–480

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 40m
    $334–925

  5. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 45m
    $116–580

  6. Fly to Nashville, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 30m
    $118–522

  7. Fly to Asheville Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Asheville Regional Airport (AVL)plane plane STL - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 22m
    $124–638

  8. Train, bus via Ossining

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York City to Knoxvillebus bus Ny
    40h 17m
    $269–737

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar73Weekly Planes
Duration4h 40mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from St Louis Bus Station to Knoxville via Port Authority Bus Terminal, 42 St-Times Square, Canal St, New York, and Knoxville in around 38h 18m.

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