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How to get fromNorth Charleston to Chicagoby plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus or bus (Greyhound)

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There are 9 ways to get from North Charleston to Chicago by plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charleston International Airport to Chicago Midway International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    4h 5m
    $89–457

  2. Bus

    1. Take the bus from Charleston Amtrak Station to Atlantabus bus Charleston
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus FlixBus 2512 / ...
    23h 45m
    $141–359

  3. Train via Petersburg (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train Silver Meteor / ...
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train Floridian
    29h 6m
    $277–1,429

  4. Drive 868.1 mi

    1. Drive from North Charleston to Chicagocar car 868.1 mi
    15h 37m
    $159–229

  5. Fly Charleston International Airport to Chicago O'Hare International Airport

    1. Fly from Charleston International Airport (CHS) to Chicago O'Hare International Airport (ORD)plane plane CHS - ORD
    4h 25m
    $114–377

  6. Bus to Myrtle Beach, fly to Chicago O'Hare International Airport

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    6h 44m
    $109–353

  7. Bus to Myrtle Beach, fly to Chicago Midway International Airport

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    6h 23m
    $99–443

  8. Bus via Madison

    1. Take the bus from Charleston Bus Station to Madisonbus bus
    2. Take the bus from Madison to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Chicago Train Stationbus bus
    29h 20m
    $160–430

  9. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train Silver Meteor / ...
    2. Take the train from Savannah Station to Chicago Union Stationtrain train Floridian
    34h 58m
    $242–796

North Charleston to Chicago by bus

Calendar14Weekly Buses
Duration23h 45mAverage Duration
Ticket$141Cheapest Price
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Questions & Answers

What companies run services between North Charleston, SC, USA and Chicago, IL, USA?

Southwest Airlines and Delta fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, you can take a bus from Charleston Amtrak Station to Chicago Bus Station via Atlanta and Atlanta Bus Station in around 23h 45m.

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