There are 6 ways to get from Mesa to Louisville by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Louisville International Airport
best- Fly from Phoenix (PHX) to Louisville International Airport (SDF)plane PHX - SDF
6h 19m$363–605Fly to Blue Grass Airport, drive
cheapest- Fly from Phoenix (PHX) to Blue Grass Airport (LEX)plane PHX - LEX
- Drive from Lexington-Airport-LEX to Louisvillecar
8h 38m$145–621Bus
- Take the bus from Phoenix Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Evansville Bus Stationbus
- Take the bus from Evansville, IN to Louisville, KYbus
40h 11m$186–452Bus, train via Chicago
- Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Stationbus
- Take the train from Flagstaff to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Indianapolistrain
- Take the bus from Indianapolis Union Station to Louisville, KYbus
47h 8m$233–1,462Drive 1,697.3 mi
- Drive from Mesa to Louisvillecar 1,697.3 mi
27h 17m$310–448Bus, train
- Take the bus from Tempe to Tucson Downtownbus
- Take the train from Tucson Amtrak Station to St. Louistrain
- Take the bus from St Louis Bus Station to Evansville Bus Stationbus
- Take the bus from Evansville, IN to Louisville, KYbus
2d 8h$251–702
Mesa to Louisville by tram and bus
Questions & Answers
The cheapest way to get from Mesa to Louisville is to bus which costs $180 - $460 and takes 40h 11m.
The fastest way to get from Mesa to Louisville is to fly which takes 6h 19m and costs $360 - $650.
The distance between Mesa and Louisville is 1529 miles. The road distance is 1707.2 miles.
The best way to get from Mesa to Louisville without a car is to bus which takes 40h 11m and costs $180 - $460.
It takes approximately 6h 19m to get from Mesa to Louisville, including transfers.
The best way to get from Mesa to Louisville is to fly which takes 6h 19m and costs $360 - $650. Alternatively, you can bus, which costs $180 - $460 and takes 40h 11m.
Louisville is 2h ahead of Mesa. It is currently 12:33 AM in Mesa and 2:33 AM in Louisville.
Yes, the driving distance between Mesa to Louisville is 1707 miles. It takes approximately 27h 17m to drive from Mesa to Louisville.
There are 557+ hotels available in Louisville.
What companies run services between Mesa, AZ, USA and Louisville, KY, USA?
Southwest Airlines, American Airlines, and United Airlines fly from Phoenix (PHX) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a vehicle from Mesa Dr/Main St to Louisville, KY via 44th St/Washington, Phoenix Sky Harbor Airport/44th Street Sky Train Station, 24th St Station, Phoenix Bus Station, St Louis Bus Station, and Evansville, IN in around 40h 11m.
- Website
- aa.com
Flights from Phoenix to Louisville International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 33m
- When
- Every day
- Estimated price
- $180–850
Flights from Phoenix to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 5h 54m
- When
- Friday and Saturday
- Estimated price
- $140–650
Flights from Phoenix to Blue Grass Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 7m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $130–600
Flights from Phoenix to Blue Grass Airport via Charlotte
- Ave. Duration
- 7h 37m
- When
- Every day
- Estimated price
- $160–700
- Website
- southwest.com
Flights from Phoenix to Louisville International Airport
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- $170–800
Flights from Phoenix to Louisville International Airport via Denver
- Ave. Duration
- 5h 27m
- When
- Monday to Saturday
- Estimated price
- $180–850
Flights from Phoenix to Louisville International Airport via Dallas
- Ave. Duration
- 5h 50m
- When
- Monday to Saturday
- Estimated price
- $180–850
Flights from Phoenix to Louisville International Airport via Nashville
- Ave. Duration
- 6h 30m
- When
- Monday to Friday
- Estimated price
- $180–850
Flights from Phoenix to Louisville International Airport via Chicago Midway
- Ave. Duration
- 7h 40m
- When
- Every day
- Estimated price
- $190–850
- Website
- delta.com
Flights from Phoenix to Blue Grass Airport via Atlanta
- Ave. Duration
- 6h 32m
- When
- Every day
- Estimated price
- $150–650
Flights from Phoenix to Blue Grass Airport via Detroit
- Ave. Duration
- 7h 36m
- When
- Every day
- Estimated price
- $150–650
- Website
- united.com
Flights from Phoenix to Louisville International Airport via Denver
- Ave. Duration
- 5h 41m
- When
- Every day
- Estimated price
- $180–850
Flights from Phoenix to Blue Grass Airport via Denver
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $130–600
Flights from Phoenix to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 28m
- When
- Every day
- Estimated price
- $140–650
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Flagstaff to Chicago Union Station
- Ave. Duration
- 32h 43m
- Frequency
- Once daily
- Estimated price
- $150–1,300
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $30–65
- Website
- https://www.amtrak.com/home.html
Train from Tucson Amtrak Station to St. Louis
- Ave. Duration
- 44h 37m
- Frequency
- 3 times a week
- Estimated price
- $160–550
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $160–470
- Coach Seat short notice purchase
- $250–550
- Business - advance purchase
- $340–1,300
- Business Class
- $460–1,200
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Phoenix Bus Station to St Louis Bus Station
- Ave. Duration
- 30h 25m
- Frequency
- Twice daily
- Estimated price
- $120–340
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Evansville Bus Station
- Ave. Duration
- 3h 35m
- Frequency
- Once daily
- Estimated price
- $29–55
- Website
- https://www.greyhound.com/
- Phone
- +1 502-368-5644 x 135
- Website
- ridewithmiller.com
Bus from Evansville, IN to Louisville, KY
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- https://ridewithmiller.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $29–50
- Schedules at
- flixbus.com
Bus from Tempe to Tucson Downtown
- Ave. Duration
- 1h 45m
- Frequency
- 5 times a day
- Estimated price
- $25–40
- Schedules at
- flixbus.com
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Indianapolis Union Station to Louisville, KY
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- https://www.amtrak.com/home.html
- Adult
- $22–45
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