There are 3 ways to get from Louisville to St. Louis by bus (Greyhound), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Louisville, KY to Evansville, INLouisville
- Take the bus from Evansville Bus Station to St Louis Bus StationGreyhound US0185
6h 50m$68–101Drive 259.1 mi
cheapest- Drive from Louisville to St. Louis259.1 mi
4h 13m$48–69Fly
- Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)SDF - STL
5h 36m$115–706
Louisville to St. Louis by bus
Questions & Answers
The cheapest way to get from Louisville to St. Louis is to drive which costs $45 - $70 and takes 4h 13m.
The fastest way to get from Louisville to St. Louis is to drive which takes 4h 13m and costs $45 - $70.
No, there is no direct bus from Louisville to St. Louis station. However, there are services departing from Louisville, KY and arriving at St Louis Bus Station via Evansville Bus Station. The journey, including transfers, takes approximately 6h 50m.
The distance between Louisville and St. Louis is 288 miles. The road distance is 260.6 miles.
The best way to get from Louisville to St. Louis without a car is to bus which takes 6h 50m and costs $65 - $110.
It takes approximately 6h 50m to get from Louisville to St. Louis, including transfers.
Louisville to St. Louis bus services, operated by Miller Transportation, depart from Louisville, KY station.
The best way to get from Louisville to St. Louis is to bus which takes 6h 50m and costs $65 - $110. Alternatively, you can fly, which costs $110 - $750 and takes 5h 36m.
Louisville to St. Louis bus services, operated by Miller Transportation, arrive at Evansville, IN station.
St. Louis is 1h behind Louisville. It is currently 6:09 PM in Louisville and 5:09 PM in St. Louis.
What companies run services between Louisville, KY, USA and St. Louis, MO, USA?
You can take a bus from Louisville, KY to St Louis Bus Station via Evansville Bus Station in around 6h 50m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) every 2 hours.
- Website
- southwest.com
Flights from Louisville International Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 3h 51m
- When
- Every day
- Estimated price
- $120–700
Flights from Louisville International Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 5h 15m
- When
- Wednesday, Thursday, and Saturday
- Estimated price
- $110–700
- Website
- delta.com
Flights from Louisville International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $150–800
Flights from Louisville International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 8m
- When
- Every day
- Estimated price
- $150–800
- Website
- united.com
Flights from Louisville International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $120–750
- Website
- aa.com
Flights from Louisville International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 6h 26m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $120–750
- Phone
- +1 502-368-5644 x 135
- Website
- ridewithmiller.com
Bus from Louisville, KY to Evansville, IN
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- https://ridewithmiller.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Evansville Bus Station to St Louis Bus Station
- Ave. Duration
- 3h 30m
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.greyhound.com/
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More Questions & Answers
Yes, the driving distance between Louisville to St. Louis is 261 miles. It takes approximately 4h 13m to drive from Louisville to St. Louis.
There are 437+ hotels available in St. Louis.