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How to get fromLouisville to Key Westby plane, bus, ferry, car or bus (Amtrak, Greyhound, Flixbus)

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There are 6 ways to get from Louisville to Key West by plane, bus, ferry, car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)planeSDF - EYW
    6h 25m
    $133–666
  2. Bus, ferry

    1. Take the bus from Louisville, KY to Nashvillebus
    2. Take the bus from Nashville Bus Station to Tallahasseebus
    3. Take the bus from Tallahassee to Fort Myersbus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry
    28h 26m
    $355–523
  3. Drive 1,175.1 mi

    1. Drive from Louisville to Key Westcar1,175.1 mi
    21h 52m
    $215–310
  4. Bus to Evansville, fly

    1. Take the bus from Louisville, KY to Evansville, INbus
    2. Fly from Evansville (EVV) to Key West International Airport (EYW)planeEVV - EYW
    8h 18m
    $220–889
  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus
    2. Fly from Covington (CVG) to Key West International Airport (EYW)planeCVG - EYW
    6h 38m
    $183–858
  6. Bus

    1. Take the bus from Louisville, KY to Nashvillebus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus
    4. Take the bus from Miami Airport Station to Big Pine Keybus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd StreetbusLks
    30h 26m
    $157–370

Louisville to Key West by bus and foot

Calendar8Weekly Services
Duration30h 26mAverage Duration
Ticket$157Cheapest Price
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Questions & Answers

What companies run services between Louisville, KY, USA and Key West, FL, USA?

Delta, American Airlines, and two other airlines fly from Louisville International Airport (SDF) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Louisville, KY to N Roosevelt & 3rd Street via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 30h 26m.

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