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How to get fromLouisville to Chicagoby plane, bus (Amtrak), bus, train or car

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There are 5 ways to get from Louisville to Chicago by plane, bus (Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)planeSDF - MDW
    3h 24m
    $69–428
  2. Bus (Amtrak)

    cheapest
    1. Take the bus from Louisville, KY to Chicago Union Stationbus
    6h
    $50–60
  3. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus
    2. Take the train from Indianapolis to Chicago Union StationtrainCardinal
    8h 20m
    $58–344
  4. Drive 294.4 mi

    1. Drive from Louisville to Chicagocar294.4 mi
    4h 59m
    $54–78
  5. Fly to Chicago O'Hare International Airport

    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)planeSDF - ORD
    3h 54m
    $204–558

Louisville to Chicago by bus (Amtrak)

Calendar14Weekly Buses
Duration6hAverage Duration
Ticket$50Cheapest Price
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Questions & Answers

What companies run services between Louisville, KY, USA and Chicago, IL, USA?

Southwest Airlines flies from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW) twice daily. Alternatively, Amtrak Thruway operates a bus from Louisville, KY to Chicago Union Station twice daily. Tickets cost $50–60 and the journey takes 6h.

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