What is the cheapest way to get from Knoxville to Des Moines?

The cheapest way to get from Knoxville to Des Moines is to drive which costs $140 - $220 and takes 13h 41m.

What is the fastest way to get from Knoxville to Des Moines?

The fastest way to get from Knoxville to Des Moines is to drive and fly which takes 4h 40m and costs $150 - $750.

How far is it from Knoxville to Des Moines?

The distance between Knoxville and Des Moines is 676 miles. The road distance is 818.9 miles.

How do I travel from Knoxville to Des Moines without a car?

The best way to get from Knoxville to Des Moines without a car is to bus and train which takes 42h 40m and costs $360 - $1,000.

How long does it take to get from Knoxville to Des Moines?

It takes approximately 4h 50m to get from Knoxville to Des Moines, including transfers.

Bus or fly from Knoxville to Des Moines?

The best way to get from Knoxville to Des Moines is to fly which takes 4h 50m and costs $280 - $1,300. Alternatively, you can bus, which costs $330 - $650 and takes 43h 27m.

What is the time difference between Knoxville and Des Moines?

Des Moines is 1h behind Knoxville. It is currently 1:36 AM in Knoxville and 12:36 AM in Des Moines.

Can I drive from Knoxville to Des Moines?

Yes, the driving distance between Knoxville to Des Moines is 819 miles. It takes approximately 13h 41m to drive from Knoxville to Des Moines.

Where can I stay near Des Moines?

There are 241+ hotels available in Des Moines.

Knoxville to Des Moines - 8 ways to travel via train, plane, bus, and car

There are 8 ways to get from Knoxville to Des Moines by plane, bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Mcghee Tyson Airport
best
1. Fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM)TYS - DSM
4h 50m
$284–1,288
Drive 814.1 mi
cheapest
1. Drive from Knoxville to Des Moines814.1 mi
13h 41m
$149–215
Bus, train
1. Take the bus from Knoxville to New York
2. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Station
3. Take the bus from Chicago to Des Moines
42h 40m
$362–958
Bus, train via Galesburg
1. Take the bus from Knoxville to New York City
2. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Station
3. Take the train from Chicago Union Station to Galesburg Amtrak Station
4. Take the bus from Galesburg to Burlington
5. Take the bus from Burlington to Des Moines
44h 11m
$340–933
Drive to Nashville, fly
1. Drive from Knoxville to Nashville-Airport-BNA
2. Fly from Nashville (BNA) to Des Moines (DSM)BNA - DSM
4h 40m
$159–717
Drive to Chattanooga Metropolitan Airport, fly
1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)
2. Fly from Chattanooga Metropolitan Airport (CHA) to Des Moines (DSM)CHA - DSM
6h 16m
$226–1,048
Drive to Asheville Regional Airport, fly
1. Drive from Knoxville to Asheville-Airport-AVL
2. Fly from Asheville Regional Airport (AVL) to Des Moines (DSM)AVL - DSM
6h 38m
$179–803
Bus
1. Take the bus from Knoxville to New York
2. Take the bus from New York Midtown to Chicago Bus Station
3. Take the bus from Chicago to Des Moines
43h 27m
$337–638

Mcghee Tyson Airport (TYS) to Des Moines (DSM) flights

65Weekly Planes

5h 24mAverage Duration

$217Cheapest Price

See schedules

Questions & Answers

Map of how to get from Knoxville to Des Moines.

Launch map view

Distance: 672.4 mi
Duration: 4h 50m

What companies run services between Knoxville, TN, USA and Des Moines, IA, USA?

Delta, American Airlines, and United Airlines fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM) every 3 hours. Alternatively, you can take a vehicle from Knoxville to Des Moines via Knoxville, New York, East Broadway, 23 St, New York Midtown, and Chicago in around 43h 27m.

Airlines

Train operators

Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.